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First Look: DNA Replication

For the first time ever, scientists have captured a single DNA molecule replicating on video — and it’s changing the way we think about the entire process. One of the most surprising findings is how much randomness characterizes the process.

“It’s a different way of thinking about replication that raises new questions,” Stephen Kowalczykowski, molecular genetics professor at University of California, Davis, said in a press release. “It’s a real paradigm shift, and undermines a great deal of what’s in the textbooks.”

The researchers watched replicating DNA from E. coli bacteria. The first step in the process always sees the double helix “unzipping” into two strands — a “leading strand” and a “lagging strand.” Each of these become a template for a new strand that is made to match it, leaving two complete DNA molecules when the process has reached the end. The researchers wanted to measure how fast the enzyme machinery moving along the different strands in opposite directions worked.

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Click link below for article and video:

https://www.nbcnews.com/mach/science/first-its-kind-dna-video-raises-big-question-about-molecule-ncna774821

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